The Crown of Thorns

Author:

Publisher:National Academies Press

ISBN:9780309186636

Total Pages:246

Viewed:684

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A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

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Fundamentals of Biomechanics

Author:Duane Knudson

Publisher:Springer Science & Business Media

ISBN:1475752989

Total Pages:337

Viewed:614

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Books Description:

Fundamentals of Biomechanics introduces the exciting world of how human movement is created and how it can be improved. Teachers, coaches and physical therapists all use biomechanics to help people improve movement and decrease the risk of injury. The book presents a comprehensive review of the major concepts of biomechanics and summarizes them in nine principles of biomechanics. Fundamentals of Biomechanics concludes by showing how these principles can be used by movement professionals to improve human movement. Specific case studies are presented in physical education, coaching, strength and conditioning, and sports medicine.

Botulinum Neurotoxins

Author:Andreas Rummel,Thomas Binz

Publisher:Springer Science & Business Media

ISBN:3642335705

Total Pages:324

Viewed:1225

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Books Description:

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

The Psychology of Fake News

Author:Rainer Greifeneder,Mariela Jaffe,Eryn Newman,Norbert Schwarz

Publisher:Routledge

ISBN:1000179052

Total Pages:240

Viewed:1644

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Books Description:

This volume examines the phenomenon of fake news by bringing together leading experts from different fields within psychology and related areas, and explores what has become a prominent feature of public discourse since the first Brexit referendum and the 2016 US election campaign. Dealing with misinformation is important in many areas of daily life, including politics, the marketplace, health communication, journalism, education, and science. In a general climate where facts and misinformation blur, and are intentionally blurred, this book asks what determines whether people accept and share (mis)information, and what can be done to counter misinformation? All three of these aspects need to be understood in the context of online social networks, which have fundamentally changed the way information is produced, consumed, and transmitted. The contributions within this volume summarize the most up-to-date empirical findings, theories, and applications and discuss cutting-edge ideas and future directions of interventions to counter fake news. Also providing guidance on how to handle misinformation in an age of “alternative facts”, this is a fascinating and vital reading for students and academics in psychology, communication, and political science and for professionals including policy makers and journalists.

Endocytosis and Signaling

Author:Christophe Lamaze,Ian Prior

Publisher:Springer

ISBN:3319967045

Total Pages:329

Viewed:1715

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Books Description:

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.

Human, All Too Human

Author:Friedrich Nietzsche

Publisher:The Floating Press

ISBN:1776527224

Total Pages:405

Viewed:501

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Books Description:

German scholar and thinker Friedrich Nietzsche began his career as a linguist and philologist, but over time, his work became increasingly philosophical in its scope. He came to embrace a radical point of view that prized personal freedom and choice over virtually everything else. In Human, All Too Human, Nietzsche explores the triumphs and tragic shortfalls of human nature in an eminently readable series of aphorisms and short vignettes.

Turn On, Tune In, Drop Out

Author:Timothy Leary

Publisher:Ronin Publishing

ISBN:1579511058

Total Pages:160

Viewed:1970

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Books Description:

Written in the psychedelic era, Turn On, Tune In, Drop Out is Timothy Leary at his best, beckoning with humor and irreverence, a vision of individual empowerment, personal responsibility, and spiritual awakening. Includes: Start Your Own Religion Education as an Addictive Process Soul Session Buddha as Drop-Out Mad Virgin of Psychedelia God's Secret Agent o Homage to Huxley The Awe-Ful See-Er o The Molecular Revolution MIT is TIM Backwards Neurological Politics "Trickster is a major figure in American Indian folk Wisdom. Also in Sufi Tales … a certain type of "rascal"-with a grin and a wink (and wisdom beyond wisdom) … in the Zen tradition this is known as the School of Crazy Wisdom … Timothy Leary-in his own inimitable way-has become the twentieth century's grand master of crazy wisdom …" - Dr. Jeffrey Mishlove

Dietary Reference Intakes for Calcium and Vitamin D

Author:Institute of Medicine,Food and Nutrition Board,Committee to Review Dietary Reference Intakes for Vitamin D and Calcium

Publisher:National Academies Press

ISBN:0309212030

Total Pages:1132

Viewed:544

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Books Description:

Calcium and vitamin D are essential nutrients for the human body. Establishing the levels of these nutrients that are needed by the North American population is based on the understanding of the health outcomes that calcium and vitamin D affect. It is also important to establish how much of each nutrient may be "too much." Dietary Reference Intakes for Calcium and Vitamin D provides reference intake values for these two nutrients. The report updates the DRI values defined in Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride, the 1997 study from the Institute of Medicine. This 2011 book provides background information on the biological functions of each nutrient, reviews health outcomes that are associated with the intake of calcium and vitamin D, and specifies Estimated Average Requirements and Recommended Dietary Allowances for both. It also identifies Tolerable Upper Intake Levels, which are levels above wish the risk for harm may increase. The book includes an overview of current dietary intake in the U.S. and Canada, and discusses implications of the study. A final chapter provides research recommendations. The DRIs established in this book incorporate current scientific evidence about the roles of vitamin D and calcium in human health and will serve as a valuable guide for a range of stakeholders including dietitians and other health professionals, those who set national nutrition policy, researchers, the food industry, and private and public health organizations and partnerships.

Introduction to Swiss Law

Author:Marc Thommen

Publisher:Carl Grossmann Verlag

ISBN:3941159240

Total Pages:552

Viewed:821

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Books Description:

What are the origins of direct democracy in Switzerland? How does the Swiss judiciary function? What are the principles of Swiss civil, contract and administrative law? What is the role of public service broadcasting in the political decision making process? What are the leading cases in tax law? What forms of euthanasia are legal in Switzerland? In this introduction 13 legal scholars of the University of Zürich Law Faculty try to answer these questions and give the reader an overview of Swiss public, private and criminal law. As the first comprehensive introduction to Swiss law in English, it is addressed to both lawyers from abroad and incoming students.

Pharmaceuticals, Corporate Crime and Public Health

Author:Graham Dukes,John Braithwaite,J P Moloney

Publisher:Edward Elgar Publishing

ISBN:1783471107

Total Pages:424

Viewed:1192

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Books Description:

The pharmaceutical industry exists to serve the community, but over the years it has engaged massively in corporate crime, with the public footing the bill. This readable study by experts in medicine, law, criminology and public health documents the pr

Global Corruption Report: Sport

Author:Transparency International

Publisher:Routledge

ISBN:1317443756

Total Pages:372

Viewed:1832

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Books Description:

Sport is a global phenomenon engaging billions of people and generating annual revenues of more than US$ 145 billion. Problems in the governance of sports organisations, fixing of matches and staging of major sporting events have spurred action on many fronts. Yet attempts to stop corruption in sport are still at an early stage. The Global Corruption Report (GCR) on sport is the most comprehensive analysis of sports corruption to date. It consists of more than 60 contributions from leading experts in the fields of corruption and sport, from sports organisations, governments, multilateral institutions, sponsors, athletes, supporters, academia and the wider anti-corruption movement. This GCR provides essential analysis for understanding the corruption risks in sport, focusing on sports governance, the business of sport, planning of major events, and match-fixing. It highlights the significant work that has already been done and presents new approaches to strengthening integrity in sport. In addition to measuring transparency and accountability, the GCR gives priority to participation, from sponsors to athletes to supporters an essential to restoring trust in sport.

Yeasts in Natural Ecosystems: Diversity

Author:Pietro Buzzini,Marc-André Lachance,Andrey Yurkov

Publisher:Springer

ISBN:3319626833

Total Pages:499

Viewed:1819

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Books Description:

This book focuses on the diversity of yeasts in aquatic and terrestrial ecosystems, including the association of yeasts with insects, invertebrate and vertebrate animals. It offers an overview of the knowledge accumulated in the course of more than 60 years of research and is closely connected with the volume Yeasts in Natural Ecosystems: Ecology by the same editors. In view of the rapid decline of many natural habitats due to anthropogenic activities and climate change, the need to study biodiversity is pressing. Rising temperatures threaten species inhabiting cold and aquatic environments, and species in terrestrial ecosystems are endangered by habitat fragmentation or loss. Most of our knowledge of intrinsic properties (autoecology) of yeasts reported throughout this book is derived from laboratory experiments with pure cultures. Accordingly, the importance of culture collections for ecological studies is highlighted by presenting an overview of worldwide available yeast strains and their origins. All of the chapters were written by leading international yeast research experts, and will appeal to researchers and advanced students in the field of microbial diversity.

Strange Blood

Author:Boel Berner

Publisher:transcript Verlag

ISBN:3839451639

Total Pages:216

Viewed:1775

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Books Description:

In the mid-1870s, the experimental therapy of lamb blood transfusion spread like an epidemic across Europe and the USA. Doctors tried it as a cure for tuberculosis, pellagra and anemia; proposed it as a means to reanimate seemingly dead soldiers on the battlefield. It was a contested therapy because it meant crossing boundaries and challenging taboos. Was the transfusion of lamb blood into desperately sick humans really defensible? The book takes the reader on a journey into hospital wards and lunatic asylums, physiological laboratories and 19th century wars. It presents a fascinating story of medical knowledge, ambitions and concerns - a story that provides lessons for current debates on the morality of medical experimentation and care.

The Psychosomatic Assessment

Author:G.A. Fava,N. Sonino,T.N. Wise

Publisher:Karger Medical and Scientific Publishers

ISBN:3805598548

Total Pages:254

Viewed:576

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Books Description:

Psychosomatic medicine has developed methods to increase diagnostic accuracy and improve targeted therapeutic approaches in all fields of medicine. In this context, clinimetrics, the science of clinical measurements, provides unprecedented opportunities for psychosomatic assessment.This volume illustrates how this approach can be translated into everyday practice complementing and improving the medical interview. The most sensitive and reliable clinical methods are presented for evaluating specific psychosocial aspects of disease, i.e. childhood adversities, life events and chronic stress, lifestyle, sexual function, subclinical and affective disturbances, personality, illness behavior, well-being and family dynamics. Each chapter provides practical illustrations as to how crucial information can be obtained with specific methods individualized according to the patients’ needs. A hyperlink is provided to a website that contains many of the instruments assessed in the volume.This book enables the reader to understand the value of the psychosomatic approach in clinical practice. It is intended to expand and refine the skills of clinicians who work in general and specialized medicine and psychiatry, whether physicians, psychologists or other health professionals.

Liver Regeneration and Carcinogenesis

Author:Gerard Meurant

Publisher:Elsevier

ISBN:9780080535548

Total Pages:402

Viewed:1353

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Books Description:

Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of researh disciplines. This book brings together current findings in a coherent manner, from a molecular point of view. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis, and liver tumor therapy. The contributors are pioneers and leaders in this field. * Logical organization of material in three detailed and comprehensive sections: liver regeneration, liver carcinogenesis, and liver tumor treatment * Contributors are pioneers and leaders in the field * There are currently no books on this subject on the market * Research focus is at the molecular level

Brain and Culture

Author:Bruce E. Wexler

Publisher:MIT Press

ISBN:0262265141

Total Pages:320

Viewed:508

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Books Description:

Research shows that between birth and early adulthood the brain requires sensory stimulation to develop physically. The nature of the stimulation shapes the connections among neurons that create the neuronal networks necessary for thought and behavior. By changing the cultural environment, each generation shapes the brains of the next. By early adulthood, the neuroplasticity of the brain is greatly reduced, and this leads to a fundamental shift in the relationship between the individual and the environment: during the first part of life, the brain and mind shape themselves to the major recurring features of their environment; by early adulthood, the individual attempts to make the environment conform to the established internal structures of the brain and mind. In Brain and Culture, Bruce Wexler explores the social implications of the close and changing neurobiological relationship between the individual and the environment, with particular attention to the difficulties individuals face in adulthood when the environment changes beyond their ability to maintain the fit between existing internal structure and external reality. These difficulties are evident in bereavement, the meeting of different cultures, the experience of immigrants (in which children of immigrant families are more successful than their parents at the necessary internal transformations), and the phenomenon of interethnic violence. Integrating recent neurobiological research with major experimental findings in cognitive and developmental psychology—with illuminating references to psychoanalysis, literature, anthropology, history, and politics—Wexler presents a wealth of detail to support his arguments. The groundbreaking connections he makes allow for reconceptualization of the effect of cultural change on the brain and provide a new biological base from which to consider such social issues as "culture wars" and ethnic violence.